ChemicalBook > CAS DataBase List > WZ8040

WZ8040

Product Name
WZ8040
CAS No.
1214265-57-2
Chemical Name
WZ8040
Synonyms
CS-471;WZ8040;WZ-8040;WZ 8040;WZ8040 USP/EP/BP;N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide;N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)thio)phenyl)acrylami;N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide;2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-;N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide WZ8040
CBNumber
CB22501011
Molecular Formula
C24H25ClN6OS
Formula Weight
481.01
MOL File
1214265-57-2.mol
More
Less

WZ8040 Property

Density 
1.37
storage temp. 
Store at -20°C
solubility 
≥24.05 mg/mL in DMSO; insoluble in H2O; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
pka
12.94±0.70(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
30062
Product name
WZ8040
Packaging
25mg
Price
$645
Updated
2024/03/01
Cayman Chemical
Product number
30062
Product name
WZ8040
Packaging
50mg
Price
$1139
Updated
2024/03/01
Cayman Chemical
Product number
30062
Product name
WZ8040
Packaging
5mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
30062
Product name
WZ8040
Packaging
10mg
Price
$290
Updated
2024/03/01
ApexBio Technology
Product number
A1393
Product name
WZ8040
Packaging
25mg
Price
$360
Updated
2021/12/16
More
Less

WZ8040 Chemical Properties,Usage,Production

Description

WZ8040 is an inhibitor of mutant EGF receptors (EGFRs) with IC50 values ranging from 2 to 306 nM in Ba/F3 cells. It is selective for EGFR mutants, including the EGFRDel E746_A750 and EGFRL858R mutations conferring gefitinib sensitivity and the EGFRDel E746_A750/T790M mutation conferring gefitinib resistance (IC50s = 2, 6, and 6 nM in Ba/F3 cells), over wild-type EGFR (IC50 = 1,820 nM in HN11 cells) but also inhibits ERBB2Ins G776V,C and wild-type ERBB2 (IC50s = 20 and 32 nM, respectively, in Ba/F3 cells). WZ8040 inhibits proliferation of PC-9 cells harboring the EGFRDel E746_A750 mutation and gefitinib-resistant PC-9 GR cells harboring the EGFRT790M resistant allele (EC50s = 6 and 8 nM, respectively).

Uses

WZ8040 is an irreversiblely EGFR T790M inhibitor (IC50<10nM).

target

EGFR T790M

References

[1] zhou w1, ercan d, chen l, yun ch, li d, capelletti m, cortot ab, chirieac l, iacob re, padera r, engen jr, wong kk, eck mj, gray ns, jänne pa. novel mutant-selective egfr kinase inhibitors against egfr t790m. nature. 2009 dec 24;462(7276):1070-4. doi: 10.1038/nature08622.

WZ8040 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

WZ8040 Suppliers

China 76 United States 14 Global 90
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2784
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52927
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58

1214265-57-2, WZ8040Related Search:

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine WZB117 WZ4002 WZ3146 Bosutinib Linifanib (ABT-869) Cryptotanshinone VX-770 Carfilzomib

  • WZ8040
  • N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide
  • CS-471
  • N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylthio)phenyl)acrylamide
  • N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide WZ8040
  • N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)thio)phenyl)acrylami
  • WZ-8040;WZ 8040
  • 2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-
  • WZ8040 USP/EP/BP
  • 1214265-57-2
  • Inhibitors